多变环境和复杂事件的表观遗传记录是细胞的衰老之源（英文）

论文摘要

虽然表观遗传和衰老的关联性已经被广泛接受,但是两者之间内在的因果关系需要深度的理论阐述和分析。本文通过分析环境与表观遗传相互作用及其过程的本质特征,证明表观遗传记录多变的细胞环境和复杂的细胞事件是细胞的衰老之源。细胞周围环境以及所经历事件可通过表观修饰激活或抑制染色体上各个基因的表达,从而对染色体模板以及基因表达模式进行塑造。外在环境和细胞历史的多变性以及内在冲突性由此被逐渐记录在染色体模板上,整体上导致染色体模板以及基因表达模式的混乱和耗散。这将导致细胞表观熵(类似于Shannon信息熵)不可避免地逐渐衰减,其混乱度可通过细胞分裂而进一步被稳定积累、记忆和扩增。另外,表观修饰应对外在环境的变化存在滞后性和一定的不可逆性,加剧了表观熵的衰退。

论文目录

1 Introduction

2 Environment and cell events may shape the DNA template into a spectrum of chromatin states through epigenetic modifications

3 Environment and cell history are imprinted and propagated on chromatin template through epigenetic modifications

4 Varied environment and complex cell events result in a dissipated spectrum of chromatin state and lead to the chaos of overall gene expression

5 Irreversibility and hysteresis of epigenetics in response to the emerging environment and new events may induce the increased loss of epigenome entropy

6 Epigenetic modifications on single copy chromatin lack the mechanisms of errorepigenetic checking and erasing

7 Cellular aging as a result and its implications on organismal aging and cell life expectancy

文章来源

类型: 期刊论文

作者: Xue-jun GUO,Dong YANG,Xiang-yuan ZHANG

关键词: 表观遗传,环境,细胞事件,细胞衰老,表观熵,甲基化

来源: Journal of Zhejiang University-Science B（Biomedicine & Biotechnology） 2019年07期

年度: 2019

分类: 工程科技Ⅱ辑,基础科学

专业: 生物学

单位: State Key Laboratory of Environment Simulation, School of Environment, Beijing Normal University,Gene Engineering and Biotechnology Beijing Key Laboratory, College of Life Sciences, Beijing Normal University

基金: Project supported by the National Key R&D Program of China(No.2017YFA0605001),the National Natural Science Foundation of China(Nos.21876011 and 91547207),the Fund for Innovative Research Group of the National Natural Science Foundation of China(No.51721093)

分类号: Q255

页码: 550-562

总页数: 13

文件大小: 865K

下载量: 67

多变环境和复杂事件的表观遗传记录是细胞的衰老之源（英文）

论文摘要

论文目录

文章来源

相关论文文献

猜你喜欢